Image Segmentation and Analysis for Automated Classification of Traumatic Pelvic Injuries

In the past decades, technical advances have allowed for the collection and storage of more types and larger quantities of medical data. The increase in the volume of existing medical data has increased the need for processing and analyzing such data. Medical data holds information that is invaluable for diagnostic as well as treatment planning purposes. Presently, a large portion of the data is not optimally used towards medical decisions because information contained in the data is inaccessible through simple human inspection, or traditional computational methods. In the field of trauma medicine, where caregivers are frequently confronted with situations where they need to make rapid decisions based on large amounts of information, the need for reliable, fast and automated computational methods for decision support systems is stringent. Such methods could process and analyze, in a timely fashion, all available medical data and provide caretakers with recommendations/predictions for both patient diagnostic and treatment planning. Presently however, even extracting features that are known to be useful for diagnosis, like presence and location of hemorrhage and fracture, is not easily achievable in automatic manner. Trauma is the main cause of death among Americans age 40 and younger; hence, it has become a national priority. A computer-aided decision making system capable of rapidly analyzing all data available for a patient and forming reliable recommendations for physicians can greatly impact the quality of care provided to patients. Such a system would also reduce the overall costs involved in patient care as it helps in optimizing the decisions, avoiding unnecessary procedures, and customizing treatments for individual patients. Among different types of trauma with a high impact on the lives of Americans, traumatic pelvic injuries, which often occur in motor vehicle accidents and in falls, have had a tremendous toll on both human lives and healthcare costs in the United States. The present project has developed automated computational methods and algorithms to analyze pelvic CT images and extract significant features describing the severity of injuries. Such a step is of great importance as every CT scan consists of tens of slices that need to be closely examined. This method can automatically extract information hidden in CT images and therefore reduce the time of the examination. The method identifies and signals areas of potential abnormality and allows the user to decide upon the action to be taken (e.g. further examination of the image and/or area and neighboring images in the scan). The project also initiates the design of a system that combines the features extracted from biomedical signals and images with information such as injury scores, injury mechanism and demographic information in order to detect the presence and the severity of Traumatic Pelvic Injuries and to provide recommendations for diagnosis and treatment. The recommendations are provided in form of grammatical rules, allowing physicians to explore the reasoning behind these assessments

Unified wavelet and gaussian filtering for segmentation of CT images; application in segmentation of bone in pelvic CT images

Background The analysis of pelvic CT scans is a crucial step for detecting and assessing the severity of Traumatic Pelvic Injuries. Automating the processing of pelvic CT scans could impact decision accuracy, decrease the time for decision making, and reduce health care cost. This paper discusses a method to automate the segmentation of bone from pelvic CT images. Accurate segmentation of bone is very important for developing an automated assisted-decision support system for Traumatic Pelvic Injury diagnosis and treatment. Methods The automated method for pelvic CT bone segmentation is a hierarchical approach that combines filtering and histogram equalization, for image enhancement, wavelet analysis and automated seeded region growing. Initial results of segmentation are used to identify the region where bone is present and to target histogram equalization towards the specific area. Speckle Reducing Anisotropic Didffusion (SRAD) filter is applied to accentuate the desired features in the region. Automated seeded region growing is performed to refine the initial bone segmentation results. Results The proposed method automatically processes pelvic CT images and produces accurate segmentation. Bone connectivity is achieved and the contours and sizes of bones are true to the actual contour and size displayed in the original image. Results are promising and show great potential for fracture detection and assessing hemorrhage presence and severity. Conclusion Preliminary experimental results of the automated method show accurate bone segmentation. The novelty of the method lies in the unique hierarchical combination of image enhancement and segmentation methods that aims at maximizing the advantages of the combined algorithms. The proposed method has the following advantages: it produces accurate bone segmentation with maintaining bone contour and size true to the original image and is suitable for automated bone segmentation from pelvic CT images

A Signal Processing Method to Explore Similarity in Protein Flexibility

Understanding mechanisms of protein flexibility is of great importance to structural biology. The ability to detect similarities between proteins and their patterns is vital in discovering new information about unknown protein functions. A Distance Constraint Model (DCM) provides a means to generate a variety of flexibility measures based on a given protein structure. Although information about mechanical properties of flexibility is critical for understanding protein function for a given protein, the question of whether certain characteristics are shared across homologous proteins is difficult to assess. For a proper assessment, a quantified measure of similarity is necessary. This paper begins to explore image processing techniques to quantify similarities in signals and images that characterize protein flexibility. The dataset considered here consists of three different families of proteins, with three proteins in each family. The similarities and differences found within flexibility measures across homologous proteins do not align with sequence-based evolutionary methods